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Sildenafil si distingue per un rapido inizio d’azione e una clearance epatica mediata da CYP3A4. Il legame proteico plasmatico raggiunge circa il 96%, garantendo una distribuzione sistemica ampia. I metaboliti inattivi vengono escreti soprattutto per via biliare. L’assorbimento è rapido, ma può subire ritardi con pasti grassi. In un quadro farmacologico completo, viagra senza ricetta mostra un equilibrio tra rapidità di effetto e emivita breve.